Package: PANACEA
Title: Personalized Network-Based Anti-Cancer Therapy Evaluation
Version: 1.1.0.9000
Authors@R: 
    person(given = "Ege",
           family = "Ulgen",
           role = c("aut", "cre", "cph"),
           email = "egeulgen@gmail.com",
           comment = c(ORCID = "0000-0003-2090-3621"))
Maintainer: Ege Ulgen <egeulgen@gmail.com>
Description: Identification of the most appropriate pharmacotherapy for
        each patient based on genomic alterations is a major challenge
        in personalized oncology. 'PANACEA' is a collection of
        personalized anti-cancer drug prioritization approaches
        utilizing network methods. The methods utilize personalized
        "driverness" scores from 'driveR' to rank drugs, mapping these
        onto a protein-protein interaction network. The
        "distance-based" method scores each drug based on these scores
        and distances between drugs and genes to rank given drugs. The
        "RWR" method propagates these scores via a random-walk with
        restart framework to rank the drugs. The methods are described
        in detail in Ulgen E, Ozisik O, Sezerman OU. 2023. PANACEA:
        network-based methods for pharmacotherapy prioritization in
        personalized oncology. Bioinformatics
        <doi:10.1093/bioinformatics/btad022>.
License: MIT + file LICENSE
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.3
URL: https://github.com/egeulgen/PANACEA,
        https://egeulgen.github.io/PANACEA/
BugReports: https://github.com/egeulgen/PANACEA/issues
biocViews:
Imports: DBI, igraph, reshape2
Suggests: org.Hs.eg.db, rmarkdown, knitr, testthat (>= 3.0.0), covr
Config/testthat/edition: 3
Depends: R (>= 4.0)
LazyData: true
LazyDataCompression: xz
VignetteBuilder: knitr
Config/pak/sysreqs: libglpk-dev libicu-dev libxml2-dev
Repository: https://egeulgen.r-universe.dev
Date/Publication: 2025-12-22 10:02:04 UTC
RemoteUrl: https://github.com/egeulgen/panacea
RemoteRef: HEAD
RemoteSha: ada001e9b5d2de1cc8c67f86e5e47c64ecc26f0a
NeedsCompilation: yes
Packaged: 2026-06-23 10:21:46 UTC; root
Author: Ege Ulgen [aut, cre, cph] (ORCID:
    <https://orcid.org/0000-0003-2090-3621>)