{ "_id": "6a13e6c6acfb0bcc41d2d3cb", "Package": "PANACEA", "Title": "Personalized Network-Based Anti-Cancer Therapy Evaluation", "Version": "1.1.0.9000", "Authors@R": "person(given = \"Ege\",\nfamily = \"Ulgen\",\nrole = c(\"aut\", \"cre\", \"cph\"),\nemail = \"egeulgen@gmail.com\",\ncomment = c(ORCID = \"0000-0003-2090-3621\"))", "Maintainer": "Ege Ulgen ", "Description": "Identification of the most appropriate pharmacotherapy for\neach patient based on genomic alterations is a major challenge\nin personalized oncology. 'PANACEA' is a collection of\npersonalized anti-cancer drug prioritization approaches\nutilizing network methods. The methods utilize personalized\n\"driverness\" scores from 'driveR' to rank drugs, mapping these\nonto a protein-protein interaction network. The\n\"distance-based\" method scores each drug based on these scores\nand distances between drugs and genes to rank given drugs. The\n\"RWR\" method propagates these scores via a random-walk with\nrestart framework to rank the drugs. The methods are described\nin detail in Ulgen E, Ozisik O, Sezerman OU. 2023. PANACEA:\nnetwork-based methods for pharmacotherapy prioritization in\npersonalized oncology. Bioinformatics\n.", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.3", "URL": "https://github.com/egeulgen/PANACEA,\nhttps://egeulgen.github.io/PANACEA/", "BugReports": "https://github.com/egeulgen/PANACEA/issues", "biocViews": "", "Config/testthat/edition": "3", "LazyData": "true", "LazyDataCompression": "xz", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "libglpk-dev libicu-dev libxml2-dev", "Repository": "https://egeulgen.r-universe.dev", "Date/Publication": "2025-12-22 10:02:04 UTC", "RemoteUrl": "https://github.com/egeulgen/panacea", "RemoteRef": "HEAD", "RemoteSha": "ada001e9b5d2de1cc8c67f86e5e47c64ecc26f0a", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-05-24 07:32:22 UTC", "User": "root" }, "Author": "Ege Ulgen [aut, cre, cph] (ORCID:\n)", "MD5sum": "0064598e1a260faa46c63f7649dc9197", "_user": "egeulgen", "_type": "src", "_file": "PANACEA_1.1.0.9000.tar.gz", "_fileid": 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