{"ID":"hsa05415","Term_Description":"Diabetic cardiomyopathy","Fold_Enrichment":3.33328,"occurrence":10,"support":0.04413,"lowest_p":8.15273e-15,"highest_p":1.57608e-10,"Up_regulated":"NCF4, MMP9, NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C, GAPDH","Down_regulated":"ATP2A2, MTOR, PDHA1, PDHB, VDAC1, SLC25A5, PARP1","Cluster":1,"Status":"Representative"}
{"ID":"hsa00190","Term_Description":"Oxidative phosphorylation","Fold_Enrichment":3.00313,"occurrence":10,"support":0.02136,"lowest_p":9.44551e-09,"highest_p":6.93673e-08,"Up_regulated":"NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C, ATP6V1D, ATP6V0E1","Down_regulated":"ATP6V0E2","Cluster":1,"Status":"Member"}
{"ID":"hsa05208","Term_Description":"Chemical carcinogenesis - reactive oxygen species","Fold_Enrichment":2.07233,"occurrence":10,"support":0.02062,"lowest_p":1.01554e-08,"highest_p":2.18102e-06,"Up_regulated":"GSTO1, NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C","Down_regulated":"VDAC1, SLC25A5, IKBKB, ABL1","Cluster":1,"Status":"Member"}
{"ID":"hsa05012","Term_Description":"Parkinson disease","Fold_Enrichment":2.36246,"occurrence":10,"support":0.0278,"lowest_p":4.24044e-08,"highest_p":9.14706e-07,"Up_regulated":"DDIT3, NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C, TXN","Down_regulated":"UBE2G1, PSMD7, CALM3, CALM1, VDAC1, SLC25A5, TUBB","Cluster":1,"Status":"Member"}
{"ID":"hsa05020","Term_Description":"Prion disease","Fold_Enrichment":2.12834,"occurrence":10,"support":0.02098,"lowest_p":5.61708e-08,"highest_p":7.84312e-06,"Up_regulated":"DDIT3, NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C, NCF4","Down_regulated":"VDAC1, SLC25A5, PSMD7, CREB1, CSNK2A2, TUBB","Cluster":1,"Status":"Member"}
{"ID":"hsa04932","Term_Description":"Non-alcoholic fatty liver disease","Fold_Enrichment":2.3011,"occurrence":10,"support":0.02062,"lowest_p":6.20793e-08,"highest_p":3.48056e-07,"Up_regulated":"DDIT3, NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C","Down_regulated":"IKBKB, FASLG","Cluster":1,"Status":"Member"}
{"ID":"hsa04260","Term_Description":"Cardiac muscle contraction","Fold_Enrichment":2.31614,"occurrence":10,"support":0.01424,"lowest_p":8.77061e-06,"highest_p":0.00004,"Up_regulated":"UQCRQ, COX6A1, COX7A2, COX7C","Down_regulated":"ATP2A2","Cluster":1,"Status":"Member"}
{"ID":"hsa04723","Term_Description":"Retrograde endocannabinoid signaling","Fold_Enrichment":1.34844,"occurrence":9,"support":0.00699,"lowest_p":0.0293,"highest_p":0.0293,"Up_regulated":"NDUFA1, NDUFB3","Down_regulated":"DAGLA, GNB1, ADCY7","Cluster":1,"Status":"Member"}
{"ID":"hsa04130","Term_Description":"SNARE interactions in vesicular transport","Fold_Enrichment":4.77265,"occurrence":10,"support":0.01424,"lowest_p":4.69552e-09,"highest_p":0.0036,"Up_regulated":"STX6","Down_regulated":"STX2, BET1L, SNAP23","Cluster":2,"Status":"Representative"}
{"ID":"hsa04714","Term_Description":"Thermogenesis","Fold_Enrichment":2.56391,"occurrence":10,"support":0.0275,"lowest_p":1.27359e-08,"highest_p":2.58341e-06,"Up_regulated":"NDUFA1, NDUFB3, UQCRQ, COX6A1, COX7A2, COX7C","Down_regulated":"ADCY7, CREB1, KDM1A, SMARCA4, ACTG1, ACTB, ARID1A, MTOR","Cluster":3,"Status":"Representative"}
{"ID":"hsa05225","Term_Description":"Hepatocellular carcinoma","Fold_Enrichment":1.6406,"occurrence":10,"support":0.02062,"lowest_p":3.43686e-06,"highest_p":3.43686e-06,"Up_regulated":"GSTO1","Down_regulated":"MTOR, ACTG1, ACTB, ARID1A, SMARCA4, BRD7","Cluster":3,"Status":"Member"}
{"ID":"hsa05132","Term_Description":"Salmonella infection","Fold_Enrichment":2.39115,"occurrence":10,"support":0.05098,"lowest_p":0.00001,"highest_p":0.00066,"Up_regulated":"DYNLT1, STX10, TLR6, LY96, TLR5, GAPDH, TXN","Down_regulated":"DYNC1H1, TUBB, RAB9A, PFN1, ACTG1, ACTB, ARF1, IKBKB","Cluster":3,"Status":"Member"}
{"ID":"hsa04530","Term_Description":"Tight junction","Fold_Enrichment":2.21481,"occurrence":10,"support":0.02224,"lowest_p":0.00002,"highest_p":0.00074,"Up_regulated":"CLDN9, MYL6B, MYL6","Down_regulated":"ARHGAP17, SCRIB, TJAP1, ACTG1, ACTB, ITGB1","Cluster":3,"Status":"Member"}
{"ID":"hsa05130","Term_Description":"Pathogenic Escherichia coli infection","Fold_Enrichment":2.24413,"occurrence":10,"support":0.02733,"lowest_p":0.0002,"highest_p":0.0002,"Up_regulated":"TLR5, GAPDH, CLDN9","Down_regulated":"ARF1, ACTG1, ACTB, TUBB, ABL1, ITGB1, IKBKB, FASLG","Cluster":3,"Status":"Member"}
{"ID":"hsa05131","Term_Description":"Shigellosis","Fold_Enrichment":2.90318,"occurrence":10,"support":0.03321,"lowest_p":0.00035,"highest_p":0.00035,"Up_regulated":"HK3, TLR5, CBX3, RRAGD","Down_regulated":"ITGB1, CRKL, ACTG1, ACTB, PFN1, ARF1, VDAC1, IKBKB, PRKCQ, PIK3R4, MTOR, FNBP1","Cluster":3,"Status":"Member"}
{"ID":"hsa04145","Term_Description":"Phagosome","Fold_Enrichment":2.84946,"occurrence":10,"support":0.00903,"lowest_p":0.001,"highest_p":0.03302,"Up_regulated":"ATP6V1D, ATP6V0E1, TLR6, NCF4","Down_regulated":"ACTG1, ACTB, HLA-DPA1, ATP6V0E2, DYNC1H1, TUBB, ITGB1","Cluster":3,"Status":"Member"}
{"ID":"hsa05110","Term_Description":"Vibrio cholerae infection","Fold_Enrichment":5.62491,"occurrence":10,"support":0.0151,"lowest_p":0.0011,"highest_p":0.0011,"Up_regulated":"ATP6V1D, ATP6V0E1","Down_regulated":"ATP6V0E2, PDIA4, ARF1, ACTG1, ACTB","Cluster":3,"Status":"Member"}
{"ID":"hsa04611","Term_Description":"Platelet activation","Fold_Enrichment":1.93644,"occurrence":10,"support":0.00687,"lowest_p":0.00119,"highest_p":0.00146,"Up_regulated":"","Down_regulated":"ADCY7, ACTG1, ACTB, ITGB1, LCP2, SNAP23","Cluster":3,"Status":"Member"}
{"ID":"hsa04919","Term_Description":"Thyroid hormone signaling pathway","Fold_Enrichment":2.27785,"occurrence":10,"support":0.02848,"lowest_p":0.00172,"highest_p":0.00172,"Up_regulated":"","Down_regulated":"SIN3A, HDAC1, MED24, ATP2A2, MTOR, ACTG1, ACTB","Cluster":3,"Status":"Member"}
{"ID":"hsa04613","Term_Description":"Neutrophil extracellular trap formation","Fold_Enrichment":2.91662,"occurrence":10,"support":0.00699,"lowest_p":0.00187,"highest_p":0.04912,"Up_regulated":"NCF4, CAMP","Down_regulated":"ACTG1, ACTB, VDAC1, SLC25A5, MTOR, HDAC1","Cluster":3,"Status":"Member"}
{"ID":"hsa05416","Term_Description":"Viral myocarditis","Fold_Enrichment":2.62496,"occurrence":10,"support":0.00755,"lowest_p":0.00204,"highest_p":0.00204,"Up_regulated":"","Down_regulated":"ABL1, ACTG1, ACTB, HLA-DPA1","Cluster":3,"Status":"Member"}
{"ID":"hsa05135","Term_Description":"Yersinia infection","Fold_Enrichment":2.33329,"occurrence":6,"support":0.00723,"lowest_p":0.00452,"highest_p":0.00958,"Up_regulated":"","Down_regulated":"ITGB1, CRKL, ACTG1, ACTB, IKBKB, TICAM1, LCP2, NFATC3","Cluster":3,"Status":"Member"}
{"ID":"hsa05100","Term_Description":"Bacterial invasion of epithelial cells","Fold_Enrichment":2.28257,"occurrence":10,"support":0.02055,"lowest_p":0.00961,"highest_p":0.00961,"Up_regulated":"","Down_regulated":"CRKL, ACTG1, ACTB, ITGB1","Cluster":3,"Status":"Member"}
{"ID":"hsa05205","Term_Description":"Proteoglycans in cancer","Fold_Enrichment":1.16377,"occurrence":4,"support":0.00629,"lowest_p":0.02232,"highest_p":0.03536,"Up_regulated":"MMP9","Down_regulated":"ACTG1, ACTB, MTOR, FASLG, ITGB1","Cluster":3,"Status":"Member"}
{"ID":"hsa05412","Term_Description":"Arrhythmogenic right ventricular cardiomyopathy","Fold_Enrichment":2.07233,"occurrence":1,"support":0.00521,"lowest_p":0.02559,"highest_p":0.02559,"Up_regulated":"","Down_regulated":"ITGB1, ACTG1, ACTB, ATP2A2","Cluster":3,"Status":"Member"}
{"ID":"hsa04520","Term_Description":"Adherens junction","Fold_Enrichment":1.78974,"occurrence":5,"support":0.00699,"lowest_p":0.03239,"highest_p":0.04284,"Up_regulated":"","Down_regulated":"ACTG1, ACTB, CSNK2A2","Cluster":3,"Status":"Member"}
{"ID":"hsa05410","Term_Description":"Hypertrophic cardiomyopathy","Fold_Enrichment":1.76963,"occurrence":1,"support":0.00521,"lowest_p":0.04095,"highest_p":0.04095,"Up_regulated":"","Down_regulated":"ITGB1, ACTG1, ACTB, ATP2A2","Cluster":3,"Status":"Member"}
{"ID":"hsa04510","Term_Description":"Focal adhesion","Fold_Enrichment":0.79948,"occurrence":6,"support":0.00605,"lowest_p":0.04158,"highest_p":0.04158,"Up_regulated":"","Down_regulated":"ITGB1, ACTG1, ACTB, CRKL","Cluster":3,"Status":"Member"}
{"ID":"hsa04966","Term_Description":"Collecting duct acid secretion","Fold_Enrichment":4.54319,"occurrence":10,"support":0.00687,"lowest_p":0.04217,"highest_p":0.04217,"Up_regulated":"ATP6V1D, ATP6V0E1","Down_regulated":"ATP6V0E2","Cluster":3,"Status":"Member"}
{"ID":"hsa05414","Term_Description":"Dilated cardiomyopathy","Fold_Enrichment":2.07233,"occurrence":1,"support":0.00521,"lowest_p":0.04969,"highest_p":0.04969,"Up_regulated":"","Down_regulated":"ITGB1, ACTG1, ACTB, ADCY7, ATP2A2","Cluster":3,"Status":"Member"}
{"ID":"hsa04921","Term_Description":"Oxytocin signaling pathway","Fold_Enrichment":2.62496,"occurrence":10,"support":0.05696,"lowest_p":7.32522e-08,"highest_p":7.32522e-08,"Up_regulated":"MYL6B, MYL6","Down_regulated":"EEF2K, EEF2, CALM3, CALM1, NFATC3, ACTG1, ACTB, ADCY7","Cluster":4,"Status":"Representative"}
{"ID":"hsa05166","Term_Description":"Human T-cell leukemia virus 1 infection","Fold_Enrichment":2.48307,"occurrence":5,"support":0.00699,"lowest_p":9.55809e-06,"highest_p":0.00394,"Up_regulated":"","Down_regulated":"TRRAP, NFATC3, IL2RB, JAK1, VDAC1, SLC25A5, ANAPC1, IKBKB, ZFP36, ADCY7, HLA-DPA1, SRF, ETS1, CREB1","Cluster":4,"Status":"Member"}
{"ID":"hsa05167","Term_Description":"Kaposi sarcoma-associated herpesvirus infection","Fold_Enrichment":2.02961,"occurrence":10,"support":0.00963,"lowest_p":0.00002,"highest_p":0.00286,"Up_regulated":"","Down_regulated":"TICAM1, JAK1, ZFP36, IKBKB, GNB1, MTOR, CALM3, CALM1, NFATC3, CREB1","Cluster":4,"Status":"Member"}
{"ID":"hsa05031","Term_Description":"Amphetamine addiction","Fold_Enrichment":2.28257,"occurrence":1,"support":0.01042,"lowest_p":0.00003,"highest_p":0.00003,"Up_regulated":"","Down_regulated":"CALM3, CALM1, CREB1, HDAC1","Cluster":4,"Status":"Member"}
{"ID":"hsa04015","Term_Description":"Rap1 signaling pathway","Fold_Enrichment":2.10251,"occurrence":10,"support":0.03347,"lowest_p":0.00004,"highest_p":0.00004,"Up_regulated":"","Down_regulated":"CALM3, CALM1, ADCY7, CRKL, LCP2, RALGDS, PFN1, EVL, ACTG1, ACTB, ITGB1","Cluster":4,"Status":"Member"}
{"ID":"hsa04971","Term_Description":"Gastric acid secretion","Fold_Enrichment":2.59042,"occurrence":10,"support":0.04196,"lowest_p":0.00004,"highest_p":0.00004,"Up_regulated":"","Down_regulated":"ACTG1, ACTB, CALM3, CALM1, ADCY7","Cluster":4,"Status":"Member"}
{"ID":"hsa05163","Term_Description":"Human cytomegalovirus infection","Fold_Enrichment":2.1188,"occurrence":6,"support":0.00712,"lowest_p":0.00006,"highest_p":0.04385,"Up_regulated":"","Down_regulated":"MTOR, IKBKB, GNB1, CALM3, CALM1, NFATC3, ADCY7, JAK1, CREB1, CRKL, IL10RA, FASLG","Cluster":4,"Status":"Member"}
{"ID":"hsa05203","Term_Description":"Viral carcinogenesis","Fold_Enrichment":1.90906,"occurrence":10,"support":0.01618,"lowest_p":0.00009,"highest_p":0.00009,"Up_regulated":"GTF2B","Down_regulated":"CREB1, JAK1, SCRIB, RBL2, HDAC1, DNAJA3, SRF","Cluster":4,"Status":"Member"}
{"ID":"hsa04713","Term_Description":"Circadian entrainment","Fold_Enrichment":2.07233,"occurrence":10,"support":0.01375,"lowest_p":0.00009,"highest_p":0.00813,"Up_regulated":"","Down_regulated":"CALM3, CALM1, CREB1, GNB1, ADCY7","Cluster":4,"Status":"Member"}
{"ID":"hsa04925","Term_Description":"Aldosterone synthesis and secretion","Fold_Enrichment":2.00889,"occurrence":1,"support":0.00521,"lowest_p":0.0001,"highest_p":0.0001,"Up_regulated":"","Down_regulated":"CREB1, DAGLA, CALM3, CALM1, ADCY7","Cluster":4,"Status":"Member"}
{"ID":"hsa04916","Term_Description":"Melanogenesis","Fold_Enrichment":1.55938,"occurrence":1,"support":0.00521,"lowest_p":0.00012,"highest_p":0.00012,"Up_regulated":"","Down_regulated":"ADCY7, CREB1, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04922","Term_Description":"Glucagon signaling pathway","Fold_Enrichment":1.93011,"occurrence":10,"support":0.01424,"lowest_p":0.00012,"highest_p":0.00793,"Up_regulated":"","Down_regulated":"CREB1, CALM3, CALM1, PDHA1, PDHB","Cluster":4,"Status":"Member"}
{"ID":"hsa04744","Term_Description":"Phototransduction","Fold_Enrichment":4.21868,"occurrence":10,"support":0.0356,"lowest_p":0.0002,"highest_p":0.0002,"Up_regulated":"","Down_regulated":"GNB1, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04270","Term_Description":"Vascular smooth muscle contraction","Fold_Enrichment":2.15328,"occurrence":10,"support":0.01399,"lowest_p":0.0003,"highest_p":0.0003,"Up_regulated":"MYL6B, MYL6","Down_regulated":"CALM3, CALM1, PRKCH, PRKCQ, ADCY7","Cluster":4,"Status":"Member"}
{"ID":"hsa04728","Term_Description":"Dopaminergic synapse","Fold_Enrichment":1.8034,"occurrence":10,"support":0.01424,"lowest_p":0.00033,"highest_p":0.02123,"Up_regulated":"PPP2R3C","Down_regulated":"CALM3, CALM1, CREB1, GNB1, COMT","Cluster":4,"Status":"Member"}
{"ID":"hsa05418","Term_Description":"Fluid shear stress and atherosclerosis","Fold_Enrichment":2.85321,"occurrence":10,"support":0.02946,"lowest_p":0.00041,"highest_p":0.00041,"Up_regulated":"GSTO1, TXN, MMP9","Down_regulated":"CALM3, CALM1, KLF2, ACTG1, ACTB, IKBKB, SUMO3","Cluster":4,"Status":"Member"}
{"ID":"hsa04261","Term_Description":"Adrenergic signaling in cardiomyocytes","Fold_Enrichment":1.60712,"occurrence":1,"support":0.00521,"lowest_p":0.00053,"highest_p":0.00053,"Up_regulated":"PPP2R3C","Down_regulated":"ADCY7, CALM3, CALM1, ATP2A2, CREB1","Cluster":4,"Status":"Member"}
{"ID":"hsa04722","Term_Description":"Neurotrophin signaling pathway","Fold_Enrichment":3.00313,"occurrence":10,"support":0.02447,"lowest_p":0.00104,"highest_p":0.00128,"Up_regulated":"","Down_regulated":"SH2B3, CRKL, FASLG, CALM3, CALM1, ABL1, MAGED1, IRAK2, IKBKB","Cluster":4,"Status":"Member"}
{"ID":"hsa05170","Term_Description":"Human immunodeficiency virus 1 infection","Fold_Enrichment":1.7371,"occurrence":10,"support":0.01375,"lowest_p":0.00105,"highest_p":0.01344,"Up_regulated":"","Down_regulated":"CRKL, MTOR, CALM3, CALM1, NFATC3, GNB1, CFL1, IKBKB, FASLG","Cluster":4,"Status":"Member"}
{"ID":"hsa04710","Term_Description":"Circadian rhythm","Fold_Enrichment":3.69134,"occurrence":4,"support":0.00835,"lowest_p":0.00108,"highest_p":0.00108,"Up_regulated":"","Down_regulated":"BHLHE40, CRY1, CREB1","Cluster":4,"Status":"Member"}
{"ID":"hsa05152","Term_Description":"Tuberculosis","Fold_Enrichment":2.18746,"occurrence":1,"support":0.00521,"lowest_p":0.00119,"highest_p":0.00119,"Up_regulated":"TLR6, CAMP","Down_regulated":"JAK1, CREB1, HLA-DPA1, CD74, IL10RA, IRAK2, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04024","Term_Description":"cAMP signaling pathway","Fold_Enrichment":0.91568,"occurrence":1,"support":0.00521,"lowest_p":0.0024,"highest_p":0.0024,"Up_regulated":"","Down_regulated":"ADCY7, CALM3, CALM1, CREB1, ATP2A2","Cluster":4,"Status":"Member"}
{"ID":"hsa04924","Term_Description":"Renin secretion","Fold_Enrichment":1.78974,"occurrence":1,"support":0.00521,"lowest_p":0.00272,"highest_p":0.00272,"Up_regulated":"","Down_regulated":"CREB1, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04720","Term_Description":"Long-term potentiation","Fold_Enrichment":1.17535,"occurrence":1,"support":0.00521,"lowest_p":0.00284,"highest_p":0.00284,"Up_regulated":"","Down_regulated":"CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa05214","Term_Description":"Glioma","Fold_Enrichment":1.57497,"occurrence":2,"support":0.0087,"lowest_p":0.004,"highest_p":0.02774,"Up_regulated":"","Down_regulated":"CALM3, CALM1, MTOR","Cluster":4,"Status":"Member"}
{"ID":"hsa04371","Term_Description":"Apelin signaling pathway","Fold_Enrichment":2.02662,"occurrence":10,"support":0.01424,"lowest_p":0.00548,"highest_p":0.02374,"Up_regulated":"","Down_regulated":"ADCY7, GNB1, CALM3, CALM1, MTOR, PIK3R4, KLF2","Cluster":4,"Status":"Member"}
{"ID":"hsa04910","Term_Description":"Insulin signaling pathway","Fold_Enrichment":1.7371,"occurrence":2,"support":0.0061,"lowest_p":0.00548,"highest_p":0.00548,"Up_regulated":"HK3","Down_regulated":"CALM3, CALM1, CRKL, MTOR, IKBKB","Cluster":4,"Status":"Member"}
{"ID":"hsa04912","Term_Description":"GnRH signaling pathway","Fold_Enrichment":1.27014,"occurrence":1,"support":0.00521,"lowest_p":0.00763,"highest_p":0.00763,"Up_regulated":"","Down_regulated":"ADCY7, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04750","Term_Description":"Inflammatory mediator regulation of TRP channels","Fold_Enrichment":2.00889,"occurrence":1,"support":0.00521,"lowest_p":0.00893,"highest_p":0.00893,"Up_regulated":"","Down_regulated":"CALM3, CALM1, ADCY7, PRKCH, PRKCQ","Cluster":4,"Status":"Member"}
{"ID":"hsa05034","Term_Description":"Alcoholism","Fold_Enrichment":1.85728,"occurrence":10,"support":0.01399,"lowest_p":0.01129,"highest_p":0.01129,"Up_regulated":"","Down_regulated":"HDAC1, GNB1, CREB1, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa05017","Term_Description":"Spinocerebellar ataxia","Fold_Enrichment":1.96872,"occurrence":10,"support":0.00712,"lowest_p":0.01262,"highest_p":0.02587,"Up_regulated":"GTF2B","Down_regulated":"VDAC1, SLC25A5, PSMD7, ATP2A2, MTOR, PIK3R4","Cluster":4,"Status":"Member"}
{"ID":"hsa05417","Term_Description":"Lipid and atherosclerosis","Fold_Enrichment":2.20791,"occurrence":10,"support":0.01399,"lowest_p":0.01335,"highest_p":0.01619,"Up_regulated":"NCF4, MMP9, LY96, TLR6, DDIT3, ABCA1","Down_regulated":"IKBKB, TICAM1, NFATC3, CALM3, CALM1, FASLG","Cluster":4,"Status":"Member"}
{"ID":"hsa05133","Term_Description":"Pertussis","Fold_Enrichment":3.62658,"occurrence":10,"support":0.00934,"lowest_p":0.01726,"highest_p":0.04463,"Up_regulated":"LY96","Down_regulated":"ITGB1, CALM3, CALM1, CFL1, TICAM1, IRF1","Cluster":4,"Status":"Member"}
{"ID":"hsa04114","Term_Description":"Oocyte meiosis","Fold_Enrichment":1.58768,"occurrence":1,"support":0.00521,"lowest_p":0.01803,"highest_p":0.01803,"Up_regulated":"CPEB3","Down_regulated":"ADCY7, ANAPC1, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04022","Term_Description":"cGMP-PKG signaling pathway","Fold_Enrichment":2.18746,"occurrence":1,"support":0.01042,"lowest_p":0.02228,"highest_p":0.02228,"Up_regulated":"","Down_regulated":"NFATC3, SRF, ATP2A2, CALM3, CALM1, ADCY7, VDAC1, SLC25A5, CREB1","Cluster":4,"Status":"Member"}
{"ID":"hsa04915","Term_Description":"Estrogen signaling pathway","Fold_Enrichment":1.43702,"occurrence":1,"support":0.00521,"lowest_p":0.02426,"highest_p":0.02426,"Up_regulated":"MMP9","Down_regulated":"ADCY7, CREB1, CALM3, CALM1","Cluster":4,"Status":"Member"}
{"ID":"hsa04936","Term_Description":"Alcoholic liver disease","Fold_Enrichment":1.6637,"occurrence":8,"support":0.00687,"lowest_p":0.02698,"highest_p":0.02698,"Up_regulated":"LY96","Down_regulated":"IKBKB, TICAM1, FASLG, LPIN1, ALDH9A1","Cluster":4,"Status":"Member"}
{"ID":"hsa04218","Term_Description":"Cellular senescence","Fold_Enrichment":2.0192,"occurrence":7,"support":0.00699,"lowest_p":0.02816,"highest_p":0.02816,"Up_regulated":"","Down_regulated":"RBL2, MTOR, ETS1, CALM3, CALM1, NFATC3, SLC25A5, VDAC1","Cluster":4,"Status":"Member"}
{"ID":"hsa04625","Term_Description":"C-type lectin receptor signaling pathway","Fold_Enrichment":2.31614,"occurrence":10,"support":0.00699,"lowest_p":0.03593,"highest_p":0.04147,"Up_regulated":"CLEC4D","Down_regulated":"CALM3, CALM1, NFATC3, IKBKB, IRF1","Cluster":4,"Status":"Member"}
{"ID":"hsa04014","Term_Description":"Ras signaling pathway","Fold_Enrichment":1.7194,"occurrence":4,"support":0.00664,"lowest_p":0.04169,"highest_p":0.04855,"Up_regulated":"","Down_regulated":"GNB1, CALM3, CALM1, RASA3, RASAL3, IKBKB, FASLG, RALGDS, ETS1, ABL1","Cluster":4,"Status":"Member"}
{"ID":"hsa04211","Term_Description":"Longevity regulating pathway","Fold_Enrichment":1.32722,"occurrence":2,"support":0.0061,"lowest_p":0.04616,"highest_p":0.04616,"Up_regulated":"","Down_regulated":"ADCY7, CREB1, MTOR","Cluster":4,"Status":"Member"}
{"ID":"hsa04064","Term_Description":"NF-kappa B signaling pathway","Fold_Enrichment":3.0582,"occurrence":10,"support":0.04133,"lowest_p":1.79259e-07,"highest_p":1.79259e-07,"Up_regulated":"LY96","Down_regulated":"PRKCQ, CARD11, TICAM1, IKBKB, PARP1, UBE2I, CSNK2A2","Cluster":5,"Status":"Representative"}
{"ID":"hsa04659","Term_Description":"Th17 cell differentiation","Fold_Enrichment":3.2812,"occurrence":10,"support":0.01424,"lowest_p":6.04865e-06,"highest_p":0.00109,"Up_regulated":"","Down_regulated":"MTOR, JAK1, HLA-DPA1, NFATC3, PRKCQ, IKBKB, GATA3, IL27RA, IL2RB","Cluster":5,"Status":"Member"}
{"ID":"hsa04931","Term_Description":"Insulin resistance","Fold_Enrichment":1.48582,"occurrence":10,"support":0.00712,"lowest_p":0.00004,"highest_p":0.04648,"Up_regulated":"","Down_regulated":"MTOR, IKBKB, PRKCQ, CREB1","Cluster":5,"Status":"Member"}
{"ID":"hsa04630","Term_Description":"JAK-STAT signaling pathway","Fold_Enrichment":1.42317,"occurrence":7,"support":0.00725,"lowest_p":0.00005,"highest_p":0.03386,"Up_regulated":"","Down_regulated":"IL2RB, IL27RA, IL10RA, JAK1, PIAS3, MTOR","Cluster":5,"Status":"Member"}
{"ID":"hsa04210","Term_Description":"Apoptosis","Fold_Enrichment":2.04163,"occurrence":10,"support":0.01471,"lowest_p":0.00006,"highest_p":0.00006,"Up_regulated":"DDIT3","Down_regulated":"FASLG, ACTG1, ACTB, PARP1, DFFB, IKBKB","Cluster":5,"Status":"Member"}
{"ID":"hsa04920","Term_Description":"Adipocytokine signaling pathway","Fold_Enrichment":1.7371,"occurrence":10,"support":0.00735,"lowest_p":0.00017,"highest_p":0.00017,"Up_regulated":"","Down_regulated":"MTOR, IKBKB, PRKCQ","Cluster":5,"Status":"Member"}
{"ID":"hsa04150","Term_Description":"mTOR signaling pathway","Fold_Enrichment":1.80144,"occurrence":10,"support":0.01375,"lowest_p":0.00045,"highest_p":0.00045,"Up_regulated":"ATP6V1D, RRAGD","Down_regulated":"WDR59, MTOR, TELO2, LPIN1, IKBKB","Cluster":5,"Status":"Member"}
{"ID":"hsa05235","Term_Description":"PD-L1 expression and PD-1 checkpoint pathway in cancer","Fold_Enrichment":3.09686,"occurrence":10,"support":0.03099,"lowest_p":0.0005,"highest_p":0.0005,"Up_regulated":"","Down_regulated":"MTOR, IKBKB, JAK1, NFATC3, TICAM1, CSNK2A2, PRKCQ","Cluster":5,"Status":"Member"}
{"ID":"hsa04660","Term_Description":"T cell receptor signaling pathway","Fold_Enrichment":1.94922,"occurrence":10,"support":0.00755,"lowest_p":0.00084,"highest_p":0.00084,"Up_regulated":"","Down_regulated":"LCP2, NFATC3, PRKCQ, CARD11, IKBKB","Cluster":5,"Status":"Member"}
{"ID":"hsa05145","Term_Description":"Toxoplasmosis","Fold_Enrichment":2.10934,"occurrence":4,"support":0.00567,"lowest_p":0.00084,"highest_p":0.00104,"Up_regulated":"LY96","Down_regulated":"JAK1, HLA-DPA1, IKBKB, ITGB1, IL10RA","Cluster":5,"Status":"Member"}
{"ID":"hsa05215","Term_Description":"Prostate cancer","Fold_Enrichment":1.62368,"occurrence":10,"support":0.01424,"lowest_p":0.00144,"highest_p":0.01079,"Up_regulated":"MMP9","Down_regulated":"CREB1, IKBKB, MTOR","Cluster":5,"Status":"Member"}
{"ID":"hsa04621","Term_Description":"NOD-like receptor signaling pathway","Fold_Enrichment":1.34231,"occurrence":10,"support":0.00755,"lowest_p":0.00506,"highest_p":0.04026,"Up_regulated":"CAMP, TXN","Down_regulated":"IKBKB, VDAC1, JAK1, TICAM1","Cluster":5,"Status":"Member"}
{"ID":"hsa04658","Term_Description":"Th1 and Th2 cell differentiation","Fold_Enrichment":3.42386,"occurrence":10,"support":0.01424,"lowest_p":0.00582,"highest_p":0.03052,"Up_regulated":"","Down_regulated":"JAK1, RUNX3, HLA-DPA1, NFATC3, PRKCQ, IKBKB, IL2RB, GATA3","Cluster":5,"Status":"Member"}
{"ID":"hsa04657","Term_Description":"IL-17 signaling pathway","Fold_Enrichment":1.71193,"occurrence":10,"support":0.00699,"lowest_p":0.00739,"highest_p":0.00739,"Up_regulated":"S100A8, S100A9, MMP9","Down_regulated":"IKBKB","Cluster":5,"Status":"Member"}
{"ID":"hsa05169","Term_Description":"Epstein-Barr virus infection","Fold_Enrichment":1.3781,"occurrence":10,"support":0.00755,"lowest_p":0.00836,"highest_p":0.03339,"Up_regulated":"","Down_regulated":"HLA-DPA1, IKBKB, JAK1, PSMD7, SIN3A, HDAC1, RUNX3","Cluster":5,"Status":"Member"}
{"ID":"hsa05212","Term_Description":"Pancreatic cancer","Fold_Enrichment":2.07233,"occurrence":10,"support":0.01011,"lowest_p":0.00924,"highest_p":0.01726,"Up_regulated":"","Down_regulated":"IKBKB, RALGDS, MTOR, JAK1","Cluster":5,"Status":"Member"}
{"ID":"hsa05164","Term_Description":"Influenza A","Fold_Enrichment":2.09686,"occurrence":10,"support":0.01399,"lowest_p":0.01093,"highest_p":0.03571,"Up_regulated":"","Down_regulated":"IKBKB, TICAM1, JAK1, HLA-DPA1, FASLG, VDAC1, SLC25A5, ACTG1, ACTB","Cluster":5,"Status":"Member"}
{"ID":"hsa04140","Term_Description":"Autophagy - animal","Fold_Enrichment":1.68747,"occurrence":10,"support":0.00712,"lowest_p":0.01104,"highest_p":0.03944,"Up_regulated":"IGBP1, RRAGD","Down_regulated":"MTOR, PIK3R4, UVRAG, PRKCQ","Cluster":5,"Status":"Member"}
{"ID":"hsa05221","Term_Description":"Acute myeloid leukemia","Fold_Enrichment":1.17535,"occurrence":10,"support":0.00712,"lowest_p":0.01183,"highest_p":0.01183,"Up_regulated":"","Down_regulated":"IKBKB, MTOR","Cluster":5,"Status":"Member"}
{"ID":"hsa05140","Term_Description":"Leishmaniasis","Fold_Enrichment":2.55678,"occurrence":6,"support":0.00723,"lowest_p":0.01335,"highest_p":0.0464,"Up_regulated":"NCF4","Down_regulated":"ITGB1, JAK1, HLA-DPA1, MARCKSL1","Cluster":5,"Status":"Member"}
{"ID":"hsa05162","Term_Description":"Measles","Fold_Enrichment":1.72442,"occurrence":10,"support":0.01701,"lowest_p":0.01915,"highest_p":0.01915,"Up_regulated":"","Down_regulated":"IKBKB, CSNK2A2, JAK1, RAB9A, FASLG, IL2RB","Cluster":5,"Status":"Member"}
{"ID":"hsa04662","Term_Description":"B cell receptor signaling pathway","Fold_Enrichment":1.99364,"occurrence":10,"support":0.00712,"lowest_p":0.01938,"highest_p":0.01938,"Up_regulated":"","Down_regulated":"NFATC3, CARD11, IKBKB, CD81","Cluster":5,"Status":"Member"}
{"ID":"hsa04068","Term_Description":"FoxO signaling pathway","Fold_Enrichment":1.53806,"occurrence":10,"support":0.00687,"lowest_p":0.02467,"highest_p":0.02467,"Up_regulated":"","Down_regulated":"IKBKB, RBL2, FASLG, KLF2, S1PR1","Cluster":5,"Status":"Member"}
{"ID":"hsa05160","Term_Description":"Hepatitis C","Fold_Enrichment":1.54409,"occurrence":10,"support":0.00687,"lowest_p":0.02659,"highest_p":0.02659,"Up_regulated":"CLDN9","Down_regulated":"CD81, TICAM1, IKBKB, JAK1, FASLG","Cluster":5,"Status":"Member"}
{"ID":"hsa05161","Term_Description":"Hepatitis B","Fold_Enrichment":1.72263,"occurrence":10,"support":0.00687,"lowest_p":0.03036,"highest_p":0.03036,"Up_regulated":"MMP9","Down_regulated":"FASLG, IKBKB, NFATC3, JAK1, CREB1, TICAM1","Cluster":5,"Status":"Member"}
{"ID":"hsa04010","Term_Description":"MAPK signaling pathway","Fold_Enrichment":1.08246,"occurrence":10,"support":0.01375,"lowest_p":0.03588,"highest_p":0.03588,"Up_regulated":"DDIT3","Down_regulated":"SRF, FASLG, MAP4K1, CRKL, NFATC3, DUSP5, IKBKB","Cluster":5,"Status":"Member"}
{"ID":"hsa04668","Term_Description":"TNF signaling pathway","Fold_Enrichment":1.77362,"occurrence":1,"support":0.00521,"lowest_p":0.04617,"highest_p":0.04617,"Up_regulated":"BAG4, MMP9","Down_regulated":"IKBKB, CREB1, IRF1","Cluster":5,"Status":"Member"}
{"ID":"hsa03040","Term_Description":"Spliceosome","Fold_Enrichment":3.85483,"occurrence":10,"support":0.0151,"lowest_p":1.92117e-07,"highest_p":0.00002,"Up_regulated":"SF3B6, LSM3, BUD31","Down_regulated":"SNRPB, SF3B2, U2AF2, PUF60, SNU13, DDX23, EIF4A3, HNRNPA1, PCBP1, SRSF8, SRSF5","Cluster":6,"Status":"Representative"}
{"ID":"hsa03013","Term_Description":"Nucleocytoplasmic transport","Fold_Enrichment":3.82275,"occurrence":10,"support":0.01424,"lowest_p":5.55967e-07,"highest_p":0.00064,"Up_regulated":"NUP214","Down_regulated":"RANGAP1, UBE2I, SUMO3, NUP62, NUP93, TNPO1, EIF4A3, RNPS1, SRRM1","Cluster":7,"Status":"Representative"}
{"ID":"hsa03015","Term_Description":"mRNA surveillance pathway","Fold_Enrichment":2.51326,"occurrence":1,"support":0.00552,"lowest_p":0.01205,"highest_p":0.01205,"Up_regulated":"PPP2R3C","Down_regulated":"EIF4A3, RNPS1, SRRM1, WDR33, DAZAP1","Cluster":7,"Status":"Member"}
{"ID":"hsa04141","Term_Description":"Protein processing in endoplasmic reticulum","Fold_Enrichment":1.45831,"occurrence":10,"support":0.01424,"lowest_p":0.00002,"highest_p":0.00002,"Up_regulated":"CKAP4, DDIT3","Down_regulated":"DDOST, EDEM1, PDIA4, UBE2G1","Cluster":8,"Status":"Representative"}
{"ID":"hsa04120","Term_Description":"Ubiquitin mediated proteolysis","Fold_Enrichment":1.69961,"occurrence":10,"support":0.00687,"lowest_p":0.04667,"highest_p":0.04667,"Up_regulated":"TRIP12","Down_regulated":"UBE2G1, UBE2I, HERC1, PIAS3, ANAPC1","Cluster":8,"Status":"Member"}
{"ID":"hsa00020","Term_Description":"Citrate cycle (TCA cycle)","Fold_Enrichment":3.93743,"occurrence":10,"support":0.01375,"lowest_p":0.00019,"highest_p":0.00135,"Up_regulated":"","Down_regulated":"MDH2, PDHA1, PDHB","Cluster":9,"Status":"Representative"}
{"ID":"hsa00620","Term_Description":"Pyruvate metabolism","Fold_Enrichment":3.35101,"occurrence":10,"support":0.00687,"lowest_p":0.00076,"highest_p":0.00531,"Up_regulated":"","Down_regulated":"PDHA1, PDHB, ALDH9A1, MDH2","Cluster":9,"Status":"Member"}
{"ID":"hsa04066","Term_Description":"HIF-1 signaling pathway","Fold_Enrichment":1.83992,"occurrence":2,"support":0.0061,"lowest_p":0.00212,"highest_p":0.00212,"Up_regulated":"HK3, GAPDH","Down_regulated":"MTOR, PDHA1, PDHB","Cluster":9,"Status":"Member"}
{"ID":"hsa05230","Term_Description":"Central carbon metabolism in cancer","Fold_Enrichment":2.28257,"occurrence":2,"support":0.0061,"lowest_p":0.02163,"highest_p":0.02163,"Up_regulated":"HK3","Down_regulated":"PDHA1, PDHB, MTOR","Cluster":9,"Status":"Member"}
{"ID":"hsa04110","Term_Description":"Cell cycle","Fold_Enrichment":1.55017,"occurrence":10,"support":0.02062,"lowest_p":0.0003,"highest_p":0.0004,"Up_regulated":"","Down_regulated":"RBL2, ABL1, HDAC1, CDKN1C, ANAPC1","Cluster":10,"Status":"Representative"}
{"ID":"hsa05220","Term_Description":"Chronic myeloid leukemia","Fold_Enrichment":2.07233,"occurrence":10,"support":0.02733,"lowest_p":0.01284,"highest_p":0.01284,"Up_regulated":"","Down_regulated":"ABL1, CRKL, IKBKB, HDAC1","Cluster":10,"Status":"Member"}
{"ID":"hsa04012","Term_Description":"ErbB signaling pathway","Fold_Enrichment":1.42317,"occurrence":10,"support":0.02062,"lowest_p":0.01672,"highest_p":0.01672,"Up_regulated":"","Down_regulated":"CRKL, ABL1, MTOR","Cluster":10,"Status":"Member"}
{"ID":"hsa04666","Term_Description":"Fc gamma R-mediated phagocytosis","Fold_Enrichment":1.6755,"occurrence":10,"support":0.00687,"lowest_p":0.02423,"highest_p":0.02819,"Up_regulated":"ASAP1","Down_regulated":"MARCKSL1, CFL1, CRKL","Cluster":10,"Status":"Member"}
{"ID":"hsa03010","Term_Description":"Ribosome","Fold_Enrichment":1.83747,"occurrence":10,"support":0.00687,"lowest_p":0.00057,"highest_p":0.00057,"Up_regulated":"MRPS18C, RPS24, MRPL33, RPL26, RPL31, RPL39","Down_regulated":"RPLP2","Cluster":11,"Status":"Representative"}
{"ID":"hsa05171","Term_Description":"Coronavirus disease - COVID-19","Fold_Enrichment":1.20358,"occurrence":10,"support":0.00687,"lowest_p":0.00307,"highest_p":0.00307,"Up_regulated":"RPS24, RPL26, RPL31, RPL39","Down_regulated":"JAK1, RPLP2, IKBKB","Cluster":11,"Status":"Member"}
{"ID":"hsa03050","Term_Description":"Proteasome","Fold_Enrichment":1.74997,"occurrence":10,"support":0.00755,"lowest_p":0.00067,"highest_p":0.00189,"Up_regulated":"","Down_regulated":"PSMD7, PSMB10","Cluster":12,"Status":"Representative"}
{"ID":"hsa03022","Term_Description":"Basal transcription factors","Fold_Enrichment":4.37493,"occurrence":4,"support":0.00567,"lowest_p":0.00085,"highest_p":0.00597,"Up_regulated":"GTF2B, GTF2H5","Down_regulated":"TAF1L, TAF4, TAF15","Cluster":13,"Status":"Representative"}
{"ID":"hsa03460","Term_Description":"Fanconi anemia pathway","Fold_Enrichment":2.41067,"occurrence":7,"support":0.00629,"lowest_p":0.00342,"highest_p":0.00342,"Up_regulated":"","Down_regulated":"TELO2, MLH1, RPA1","Cluster":14,"Status":"Representative"}
{"ID":"hsa03430","Term_Description":"Mismatch repair","Fold_Enrichment":5.13578,"occurrence":10,"support":0.00735,"lowest_p":0.03754,"highest_p":0.0478,"Up_regulated":"","Down_regulated":"MLH1, RPA1, POLD2","Cluster":14,"Status":"Member"}
{"ID":"hsa00330","Term_Description":"Arginine and proline metabolism","Fold_Enrichment":4.92179,"occurrence":7,"support":0.00629,"lowest_p":0.01578,"highest_p":0.04697,"Up_regulated":"ARG1","Down_regulated":"CKB, ALDH9A1, CNDP2, PYCR2, GOT1","Cluster":15,"Status":"Representative"}
{"ID":"hsa00062","Term_Description":"Fatty acid elongation","Fold_Enrichment":3.42386,"occurrence":1,"support":0.00552,"lowest_p":0.02444,"highest_p":0.02444,"Up_regulated":"","Down_regulated":"HADH, ECHS1","Cluster":16,"Status":"Representative"}
{"ID":"hsa00650","Term_Description":"Butanoate metabolism","Fold_Enrichment":4.54319,"occurrence":1,"support":0.00552,"lowest_p":0.03137,"highest_p":0.03137,"Up_regulated":"","Down_regulated":"HADH, ECHS1, HMGCL","Cluster":16,"Status":"Member"}
{"ID":"hsa03060","Term_Description":"Protein export","Fold_Enrichment":1.78974,"occurrence":3,"support":0.00552,"lowest_p":0.03002,"highest_p":0.03002,"Up_regulated":"","Down_regulated":"SRP54","Cluster":17,"Status":"Representative"}